Important Studies on Chromium Supplementation

An article found in the Journal of American Diabetes Association found some interesting factors about Chromium.

The acute metabolic effects of glucose tolerance factor (GTF), the biologically active form of trivalent chromium, were studied in normal and genetically diabetic (db/db) mice. A single intraperitoneal injection of GTF significantly reduced the nonfasting plasma glucose level in normal mice by 38 per cent, and in diabetic mice by 14 to 29 per cent. Time course studies in normal and diabetic mice showed a maximal lowering of plasma glucose at four hours after GTF treatment. Furthermore, a single injection of GTF significantly lowered the elevated plasma triglyceride and cholesterol levels by 47 and 35 per cent, respectively, four hours after injection. Genetically diabetic mice are refractory to insulin, and treatment with exogenous insulin produced a smaller decrement in plasma glucose (11-18 per cent). The combination treatment of diabetic mice with GTF and exogenous insulin was significantly more effective in reducing plasma glucose (39-51 per cent) and triglycerides (76 per cent) than either treatment alone. These findings are consistent with the suggestion that GTF and insulin act synergistically.

This study done on GTF, the biologically active form of trivalent chromium, explains and shows how Chromium and insulin work together to reduce plasma glucose.

Study 2

Another interesting study done on Niacin Bound Chromium (NBC) was published in the Journal of Physiological Genomics

Obesity is associated with hypertension and a greater risk for cardiovascular disease as a result of elevated levels of circulating total cholesterol, LDL, and triglycerides, which are known to induce atherosclerosis. While NBC supplementation had no significant effect on age-dependent weight gain in the Lepr^dbobese diabetic mice, there were significant differences in the blood lipid profiles between NBC- and PBO-supplemented groups. Lepr^db mice supplemented with NBC had significantly (20%) lower total cholesterol, higher (25%) HDL cholesterol, lower (54%) LDL cholesterol, and lower (43%) triglyceride levels compared with PBO-gavaged mice following 6 wk of supplementation. The total cholesterol (TC)-to-HDL ratio (TC:HDL) is frequently used to assess the risk of heart disease. Following 6 wk of oral supplementation, mice treated with NBC had a significantly lower (37%) TC:HDL ratio compared with mice in the PBO group orally gavaged with a matching volume of water.

This study shows how niacin bound chromium has been found to lower total cholesterol levels and increases HDL cholesterol (good cholesterol) while lowering LDL cholesterol (bad cholesterol). The study also found that Niacin Bound Chromium reduces triglyceride levels which is linked to coronary artery disease.

Chromium has proven to be usefull in a number of ways to help out the human body. Taking a chromium picolinate supplementation such as chromax, which is found in Phentermine, can help reduce problems that people may face from not maintaining a healthy diet. More and more research continues to come out on the benefits of chromium supplementation and for people looking for a way to help improve health this extract can be of great use not only to help with improved cholesterol levels and blood sugar levels, but also as a weight loss diet approach.

Refrences

Rink, C. Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Lepr(db) obese diabetic mice with niacin-bound chromium. PHYSIOLOGICAL GENOMICS Volume: 27 Issue: 3 Pages: 370-379 Published: NOV 27 2006

R. W. Tuman and R. J. Doisy. Metabolic effects of the glucose tolerance factor (GTF) in normal and genetically diabetic mice. Diabetes: September 1977 vol. 26 no. 9 820-826

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